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Reversal of Cardiac Hypertrophy and Fibrosis from Pressure-Overload by Tetrahydrobiopterin: Efficacy of re-coupling nitric oxide synthase as a therapeutic strategy
BACKGROUND: Sustained pressure-overload induces pathologic cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. We tested whether tetrahydrobiopterin (BH4) can re-couple NOS and reverse pre-established advanced hypertrophy...
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主要な著者: | , , , , , , , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2008
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614930/ https://ncbi.nlm.nih.gov/pubmed/18474817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.737031 |
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