Reversal of Cardiac Hypertrophy and Fibrosis from Pressure-Overload by Tetrahydrobiopterin: Efficacy of re-coupling nitric oxide synthase as a therapeutic strategy

BACKGROUND: Sustained pressure-overload induces pathologic cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. We tested whether tetrahydrobiopterin (BH4) can re-couple NOS and reverse pre-established advanced hypertrophy...

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Autori principali: Moens, An L., Takimoto, Eiki, Tocchetti, Carlo G., Chakir, Khalid, Bedja, Djahida, Cormaci, Gianfranco, Ketner, Elizabeth A., Majmudar, Maulik, Gabrielson, Kathleen, Halushka, Marc K., Mitchell, James B., Biswal, Shyam, Channon, Keith M., Wolin, Mike S., Alp, Nicholas J., Paolocci, Nazareno, Champion, Hunter C., Kass, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614930/
https://ncbi.nlm.nih.gov/pubmed/18474817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.737031
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