Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

GRP78/BiP has recently emerged as a novel biomarker for aggressive prostate cancer. Here, we report that homozygous deletion of Grp78 specifically in mouse prostate epithelium suppresses prostate tumorigenesis without affecting postnatal prostate development and growth. Mouse prostates with double c...

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Bibliographic Details
Main Authors: Fu, Yong, Wey, Shiuan, Wang, Miao, Ye, Risheng, Liao, Chun-Peng, Roy-Burman, Pradip, Lee, Amy S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614780/
https://ncbi.nlm.nih.gov/pubmed/19033462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807691105
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