Akt activates NOS3 and separately restores barrier integrity in H(2)O(2)-stressed human cardiac microvascular endothelium

The integrity of microvascular endothelium is an important regulator of myocardial contractility. Microvascular barrier integrity could be altered by increased reactive oxygen species (ROS) stress seen within minutes after cardiac arrest resuscitation. Akt and its downstream target nitric oxide (NO)...

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Detalhes bibliográficos
Main Authors: Dossumbekova, Anar, Berdyshev, Evgeny V., Gorshkova, Irina, Shao, Zuohui, Li, Changqing, Long, Phillip, Joshi, Atul, Natarajan, Viswanathan, Vanden Hoek, Terry L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614535/
https://ncbi.nlm.nih.gov/pubmed/18931031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00501.2008
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