Critical role of Naip5 in inflammasome activation by a conserved C-terminal domain of flagellin

Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes, and what they sense, remain poorly defined. Here we demonstrate that 35 amino acids from the C-terminus of flagellin t...

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Detalhes bibliográficos
Main Authors: Lightfield, Karla L., Persson, Jenny, Brubaker, Sky W., Witte, Chelsea E., von Moltke, Jakob, Dunipace, Eric A., Henry, Thomas, Sun, Yao-Hui, Cado, Dragana, Dietrich, William F., Monack, Denise M., Tsolis, Renée M., Vance, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614210/
https://ncbi.nlm.nih.gov/pubmed/18724372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1646
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