Critical role of Naip5 in inflammasome activation by a conserved C-terminal domain of flagellin

Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes, and what they sense, remain poorly defined. Here we demonstrate that 35 amino acids from the C-terminus of flagellin t...

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Autores principales: Lightfield, Karla L., Persson, Jenny, Brubaker, Sky W., Witte, Chelsea E., von Moltke, Jakob, Dunipace, Eric A., Henry, Thomas, Sun, Yao-Hui, Cado, Dragana, Dietrich, William F., Monack, Denise M., Tsolis, Renée M., Vance, Russell E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614210/
https://ncbi.nlm.nih.gov/pubmed/18724372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1646
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