INHIBITION OF NEUROBLASTOMA XENOGRAFT GROWTH BY HSP90 INHIBITOR

BACKGROUND: Advanced-stage neuroblastomas are often resistant to chemotherapy. Heat shock protein (Hsp) 90 is a molecular chaperone that maintains the stability of important signal transduction proteins. We have previously reported that geldanamycin (GA), Hsp90 inhibitor, decreases Raf-1 and Akt pro...

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Main Authors: Kang, Junghee, Kamal, Adeela, Burrows, Francis J., Evers, B. Mark, Chung, Dai H.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613690/
https://ncbi.nlm.nih.gov/pubmed/16827123
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