ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia

The zeta-associated protein of 70 kDa (ZAP-70) is expressed in patients with aggressive chronic lymphocytic leukemia (CLL). We found that ZAP-70(+) CLL cells expressed activated heat-shock protein 90 (Hsp90) with high binding affinity for Hsp90 inhibitors, such as 17-allyl-amino-demethoxy-geldanamyc...

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Detalhes bibliográficos
Main Authors: Castro, Januario E., Prada, Carlos E., Loria, Olivier, Kamal, Adeela, Chen, Liguang, Burrows, Francis J., Kipps, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895276/
https://ncbi.nlm.nih.gov/pubmed/15972449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1099
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