Infiltration of CD4(+) lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here w...

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Détails bibliographiques
Auteurs principaux: Brochard, Vanessa, Combadière, Béhazine, Prigent, Annick, Laouar, Yasmina, Perrin, Aline, Beray-Berthat, Virginie, Bonduelle, Olivia, Alvarez-Fischer, Daniel, Callebert, Jacques, Launay, Jean-Marie, Duyckaerts, Charles, Flavell, Richard A., Hirsch, Etienne C., Hunot, Stéphane
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613467/
https://ncbi.nlm.nih.gov/pubmed/19104149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36470
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