Infiltration of CD4(+) lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here w...

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Detalhes bibliográficos
Main Authors: Brochard, Vanessa, Combadière, Béhazine, Prigent, Annick, Laouar, Yasmina, Perrin, Aline, Beray-Berthat, Virginie, Bonduelle, Olivia, Alvarez-Fischer, Daniel, Callebert, Jacques, Launay, Jean-Marie, Duyckaerts, Charles, Flavell, Richard A., Hirsch, Etienne C., Hunot, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613467/
https://ncbi.nlm.nih.gov/pubmed/19104149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36470
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