Infiltration of CD4(+) lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here w...

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主要な著者: Brochard, Vanessa, Combadière, Béhazine, Prigent, Annick, Laouar, Yasmina, Perrin, Aline, Beray-Berthat, Virginie, Bonduelle, Olivia, Alvarez-Fischer, Daniel, Callebert, Jacques, Launay, Jean-Marie, Duyckaerts, Charles, Flavell, Richard A., Hirsch, Etienne C., Hunot, Stéphane
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2008
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613467/
https://ncbi.nlm.nih.gov/pubmed/19104149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36470
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