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THE NOVEL CALPAIN INHIBITOR A-705253 POTENTLY INHIBITS OLIGOMERIC BETA-AMYLOID-INDUCED DYNAMIN 1 AND TAU CLEAVAGE IN HIPPOCAMPAL NEURONS
We have previously shown that beta-amyloid (Aβ) oligomers induced dynamin 1 and tau cleavage in cultured hippocampal neurons. As a result of this cleavage, dynamin 1 levels decreased and a toxic tau fragment was generated. Aβ-induced cleavage of these proteins was calpain-mediated and impacted both...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613265/ https://ncbi.nlm.nih.gov/pubmed/18590784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2008.06.003 |
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