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CASPASE-3- AND CALPAIN-MEDIATED TAU CLEAVAGE ARE DIFFERENTIALLY PREVENTED BY ESTROGEN AND TESTOSTERONE IN BETA-AMYLOID-TREATED HIPPOCAMPAL NEURONS
A growing body of evidence suggests that the proteolytic cleavage of the microtubule-associated protein tau, the main component of neurofibrillary tangles, might play a role in the molecular mechanisms underlying beta-amyloid (Aβ)-induced neurotoxicity in central neurons. In the present study, we an...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1955430/ https://ncbi.nlm.nih.gov/pubmed/17055174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2006.09.012 |
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