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Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(−/−) mice
Ku80 is important in the repair of DNA double-strand breaks by its essential function in non-homologous end-joining. The absence of Ku80 causes the accumulation of DNA damage and leads to premature ageing in mice. We showed that mouse embryonic fibroblasts (MEFs) from ku80(−/−) mice senesced rapidly...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613205/ https://ncbi.nlm.nih.gov/pubmed/19079133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.220 |
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