Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing

Our variant ascertainment algorithm VAAL uses massively parallel DNA sequence data to identify differences between bacterial genomes at high sensitivity and specificity. VAAL found ~98% of differences (including large indels) between pairs of strains from three species while calling no false positiv...

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Bibliografiske detaljer
Main Authors: Nusbaum, Chad, Ohsumi, Toshiro K., Gomez, James, Aquadro, John, Victor, Thomas C., Warren, Robert M., Hung, Deborah T., Birren, Bruce W., Lander, Eric S., Jaffe, David B.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613166/
https://ncbi.nlm.nih.gov/pubmed/19079253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1286
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