High-resolution mapping of copy-number alterations with massively parallel sequencing

Cancer results from somatic alterations in key genes, including point mutations, copy number alterations and structural rearrangements. A powerful way to discover cancer-causing genes is to identify genomic regions that show recurrent copy-number alterations (gains and losses) in tumor genomes. Rece...

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Bibliografiske detaljer
Main Authors: Chiang, Derek Y., Getz, Gad, Jaffe, David B., O’Kelly, Michael J. T., Zhao, Xiaojun, Carter, Scott L., Russ, Carsten, Nusbaum, Chad, Meyerson, Matthew, Lander, Eric S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630795/
https://ncbi.nlm.nih.gov/pubmed/19043412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1276
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