The Neurosteroid Environment in the Hippocampus Exerts Bi-Directional Effects on Seizure Susceptibility in Mice

The progesterone derivative allopregnanolone (ALLO) rapidly potentiates γ-aminobutyric acid(A) (GABA(A)) receptor mediated inhibition. The present studies determined whether specific manipulation of neurosteroid levels in the hippocampus would alter seizure susceptibility in an animal model genetica...

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Bibliographic Details
Main Authors: Gililland-Kaufman, Katherine R., Tanchuck, Michelle A., Ford, Matthew M., Crabbe, John C., Beadles-Bohling, Amy S., Snelling, Christopher, Mark, Gregory P., Finn, Deborah A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613069/
https://ncbi.nlm.nih.gov/pubmed/18840414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.09.042
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