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Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure-Prone Mice
BACKGROUND: Allopregnanolone (ALLO) is a potent positive modulator of γ-aminobutyric acid(A) receptors (GABA(A)Rs) that affects ethanol withdrawal. Finasteride (FIN), a 5α-reductase inhibitor that blocks the formation of ALLO and other GABAergic neurosteroids, alters ethanol sensitivity. Recently, w...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3620817/ https://ncbi.nlm.nih.gov/pubmed/23278716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12027 |
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