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Cytotoxic T lymphocyte-promoting effects of CD40 stimulation outweigh B cell stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus

CD40/CD40L signaling promotes both B cell and CTL responses in vivo, the latter being beneficial in tumor models. Because CTL may also limit autoreactive B cell expansion in lupus, we asked whether an agonist CD40 mAb would exacerbate lupus due to B cell stimulation or would improve lupus due to CTL...

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Bibliografski detalji
Glavni autori: Puliaev, Roman, Puliaeva, Irina, Welniak, Lisbeth, Ryan, Abigail, Haas, Mark, Murphy, William, Via, Charles S.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613003/
https://ncbi.nlm.nih.gov/pubmed/18566369
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