Inactivation of Rho GTPases by Statins Attenuates Anthrax Lethal Toxin Activity

Anthrax lethal factor (LF), secreted by Bacillus anthracis, interacts with protective antigen to form a bipartite toxin (lethal toxin [LT]) that exerts pleiotropic biological effects resulting in subversion of the innate immune response. Although the mitogen-activated protein kinase kinases (MKKs) a...

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Bibliographic Details
Main Authors: deCathelineau, Aimee M., Bokoch, Gary M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612271/
https://ncbi.nlm.nih.gov/pubmed/18936176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01005-08
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