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mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft

BACKGROUND: Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not been defined under physiological conditions. In or...

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Detalhes bibliográficos
Main Authors: Magda, Darren, Lecane, Philip, Prescott, Julia, Thiemann, Patricia, Ma, Xuan, Dranchak, Patricia K, Toleno, Donna M, Ramaswamy, Krishna, Siegmund, Kimberly D, Hacia, Joseph G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612029/
https://ncbi.nlm.nih.gov/pubmed/18980691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-521
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