Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose

Increased nuclear protein O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) mediated by high glucose treatment or the hyperglycemia of diabetes mellitus contributes to cardiac myocyte dysfunction. However, whether mitochondrial proteins in cardiac myocytes are also submitted to O-GlcNAc...

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Main Authors: Hu, Yong, Suarez, Jorge, Fricovsky, Eduardo, Wang, Hong, Scott, Brian T., Trauger, Sunia A., Han, Wenlong, Hu, Ying, Oyeleye, Mary O., Dillmann, Wolfgang H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610513/
https://ncbi.nlm.nih.gov/pubmed/19004814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808518200
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