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Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
Nurr1 is a transcription factor critical for the development of midbrain dopaminergic (DA) neurons. This study modified mouse embryonic stem (ES) cells to constitutively express Nurr1 under the elongation factor-1α promoter. The Nurr1-expression in ES cells lead to up-regulation of all DA neuronal m...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610444/ https://ncbi.nlm.nih.gov/pubmed/12453046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1460-9568.2002.02255.x |
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