Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons

Nurr1 is a transcription factor critical for the development of midbrain dopaminergic (DA) neurons. This study modified mouse embryonic stem (ES) cells to constitutively express Nurr1 under the elongation factor-1α promoter. The Nurr1-expression in ES cells lead to up-regulation of all DA neuronal m...

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Main Authors: Chung, Sangmi, Sonntag, Kai-C., Andersson, Therese, Bjorklund, Lars M., Park, Jae-Joon, Kim, Dong-Wook, Kang, Un Jung, Isacson, Ole, Kim, Kwang-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610444/
https://ncbi.nlm.nih.gov/pubmed/12453046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1460-9568.2002.02255.x
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