Cell Cycle Arrest by Kynurenine in Lens Epithelial Cells

PURPOSE: Indolemine 2,3-dioxygenase (IDO)-mediated oxidation of tryptophan produces kynurenines (KYNs), which may play a role in cataract formation. The molecular mechanisms by which KYNs cause cellular changes are poorly understood. The effects of KYNs on mouse lens epithelial cells by overexpressi...

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Bibliografiske detaljer
Main Authors: Mailankot, Maneesh, Smith, Dawn, Howell, Scott, Wang, Benlian, Jacobberger, James W., Stefan, Tammy, Nagaraj, Ram H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610264/
https://ncbi.nlm.nih.gov/pubmed/18676626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.08-2374
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