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Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens

Indoleamine 2,3-dioxygenase (IDO) is the first enzyme in the kynurenine pathway. The kynurenines formed in this pathway chemically modify proteins and cause apoptosis in cells. Evidence suggests that kynurenines and their protein modifications are involved in cataract formation, but this has yet to...

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書誌詳細
主要な著者: Mailankot, Maneesh, Staniszewska, Magdalena, Butler, Heather, Caprara, Moonkyung, Howell, Scott, Wang, Benlian, Doller, Catherine, Reneker, Lixing, Nagaraj, Ram H
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722445/
https://ncbi.nlm.nih.gov/pubmed/19308046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.22
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