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Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells

Fibroblast growth factor-2 (FGF2)-mediated signaling plays an important role in fiber cell differentiation in eye lens. We had previously shown that kynurenine (KYN) produced from the overexpression of indoleamine 2,3-dioxygenase (IDO) causes defects in the differentiation of fiber cells, induces fi...

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Detalhes bibliográficos
Main Authors: Mailankot, Maneesh, Howell, Scott, Nagaraj, Ram H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893274/
https://ncbi.nlm.nih.gov/pubmed/20478381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.05.005
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