Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma

Brain tumors can arise following deregulation of signaling pathways normally activated during brain development and may derive from neural stem cells. Given the requirement for Hedgehog in non-neoplastic stem cells, we investigated whether Hedgehog blockade could target the stem-like population in g...

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Detaylı Bibliyografya
Asıl Yazarlar: Bar, Eli E., Chaudhry, Aneeka, Lin, Alex, Fan, Xing, Schreck, Karisa, Matsui, William, Piccirillo, Sara, Vescovi, Angelo L., Dimeco, Francesco, Olivi, Alessandro, Eberhart, Charles G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610257/
https://ncbi.nlm.nih.gov/pubmed/17628016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2007-0166
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