The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance

PURPOSE: Multiple developmental pathways including Notch, Hedgehog, and Wnt are active in malignant brain tumors such as medulloblastoma and glioblastoma (GBM). This raises the possibility that tumors might compensate for therapy directed against one pathway by upregulating a different one. We inves...

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Bibliografiske detaljer
Main Authors: Schreck, Karisa C., Taylor, Pete, Marchionni, Luigi, Gopalakrishnan, Vidya, Bar, Eli E., Gaiano, Nicholas, Eberhart, Charles G.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059501/
https://ncbi.nlm.nih.gov/pubmed/21169257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1624
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