Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly

Bipolar spindle assembly critically depends on the microtubule plus-end-directed motor Eg5 that binds antiparallel microtubules and slides them in opposite directions. As such, Eg5 can produce the necessary outward force within the spindle that drives centrosome separation and inhibition of this ant...

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Bibliographic Details
Main Authors: Tanenbaum, Marvin E, Macůrek, Libor, Galjart, Niels, Medema, René H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2609737/
https://ncbi.nlm.nih.gov/pubmed/19020519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.242
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