Human hyperimmune globulin protects against the cytotoxic action of staphylococcal alpha-toxin in vitro and in vivo.

Alpha-toxin, the major cytolysin of Staphylococcus aureus, preferentially attacks human platelets and cultured monocytes, thereby promoting coagulation and the release of interleukin-1 and tumor necrosis factor. Titers of naturally occurring antibodies in human blood are not high enough to substanti...

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Pubblicato in:	Infect Immun
Autori principali:	Bhakdi, S, Mannhardt, U, Muhly, M, Hugo, F, Ronneberger, H, Hungerer, K D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC260792/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2777380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.57.10.3214-3220.1989
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