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Low doses of α(2)-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance
BACKGROUND AND PURPOSE: Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and α(2)-adrenoceptors, this study investigated whether...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2607212/ https://ncbi.nlm.nih.gov/pubmed/18806811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.353 |
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