Low doses of α(2)-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance

BACKGROUND AND PURPOSE: Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and α(2)-adrenoceptors, this study investigated whether...

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Autors principals: Milne, B, Sutak, M, Cahill, C M, Jhamandas, K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2607212/
https://ncbi.nlm.nih.gov/pubmed/18806811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.353
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