UBF levels determine the number of active ribosomal RNA genes in mammals

In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that depletion of the transcription factor upstream binding factor (UBF) leads to the stable and reversible methylation-independent sil...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Quin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2008
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606969/
https://ncbi.nlm.nih.gov/pubmed/19103806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200805146
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