c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor...

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Bibliografiske detaljer
Main Authors: Poortinga, Gretchen, Wall, Meaghan, Sanij, Elaine, Siwicki, Kasia, Ellul, Jason, Brown, Daniel, Holloway, Timothy P., Hannan, Ross D., McArthur, Grant A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082905/
https://ncbi.nlm.nih.gov/pubmed/21177653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1205
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