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A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β
The circadian clock controls daily oscillations of gene expression at the cellular level. We report the development of a high-throughput circadian functional assay system that consists of luminescent reporter cells, screening automation, and a data analysis pipeline. We applied this system to furthe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2606900/ https://ncbi.nlm.nih.gov/pubmed/19104043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811410106 |
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