High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies. To apply chemical biology methods to modulate and dissect the clock mechanism with new chemical probes, we performed a circadian screen of ∼120,...

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Main Authors: Hirota, Tsuyoshi, Lee, Jae Wook, Lewis, Warren G., Zhang, Eric E., Breton, Ghislain, Liu, Xianzhong, Garcia, Michael, Peters, Eric C., Etchegaray, Jean-Pierre, Traver, David, Schultz, Peter G., Kay, Steve A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001897/
https://ncbi.nlm.nih.gov/pubmed/21179498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000559
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