Targeting QseC Signaling and Virulence for Antibiotic Development

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits...

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Bibliografische gegevens
Hoofdauteurs: Rasko, David A., Moreira, Cristiano G., Li, De Run, Reading, Nicola C., Ritchie, Jennifer M., Waldor, Matthew K., Williams, Noelle, Taussig, Ron, Wei, Shuguang, Roth, Michael, Hughes, David T., Huntley, Jason F., Fina, Maggy W., Falck, John R., Sperandio, Vanessa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605406/
https://ncbi.nlm.nih.gov/pubmed/18719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160354
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