Targeting QseC Signaling and Virulence for Antibiotic Development

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits...

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Detalles Bibliográficos
Autores principales: Rasko, David A., Moreira, Cristiano G., Li, De Run, Reading, Nicola C., Ritchie, Jennifer M., Waldor, Matthew K., Williams, Noelle, Taussig, Ron, Wei, Shuguang, Roth, Michael, Hughes, David T., Huntley, Jason F., Fina, Maggy W., Falck, John R., Sperandio, Vanessa
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605406/
https://ncbi.nlm.nih.gov/pubmed/18719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160354
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