Targeting QseC Signaling and Virulence for Antibiotic Development

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits...

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Bibliografiske detaljer
Main Authors: Rasko, David A., Moreira, Cristiano G., Li, De Run, Reading, Nicola C., Ritchie, Jennifer M., Waldor, Matthew K., Williams, Noelle, Taussig, Ron, Wei, Shuguang, Roth, Michael, Hughes, David T., Huntley, Jason F., Fina, Maggy W., Falck, John R., Sperandio, Vanessa
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605406/
https://ncbi.nlm.nih.gov/pubmed/18719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160354
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