Targeting QseC Signaling and Virulence for Antibiotic Development

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits...

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Bibliografiset tiedot
Päätekijät: Rasko, David A., Moreira, Cristiano G., Li, De Run, Reading, Nicola C., Ritchie, Jennifer M., Waldor, Matthew K., Williams, Noelle, Taussig, Ron, Wei, Shuguang, Roth, Michael, Hughes, David T., Huntley, Jason F., Fina, Maggy W., Falck, John R., Sperandio, Vanessa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605406/
https://ncbi.nlm.nih.gov/pubmed/18719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160354
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