Targeting QseC Signaling and Virulence for Antibiotic Development

Many bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits...

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Detalhes bibliográficos
Main Authors: Rasko, David A., Moreira, Cristiano G., Li, De Run, Reading, Nicola C., Ritchie, Jennifer M., Waldor, Matthew K., Williams, Noelle, Taussig, Ron, Wei, Shuguang, Roth, Michael, Hughes, David T., Huntley, Jason F., Fina, Maggy W., Falck, John R., Sperandio, Vanessa
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605406/
https://ncbi.nlm.nih.gov/pubmed/18719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1160354
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