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Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention
The collecting duct (CD) endothelin (ET) system regulates blood pressure (BP) and Na excretion. CD-specific knockout (KO) of ET-1 causes hypertension, CD-specific KO of the ETA receptor does not alter BP, while CD-specific KO of the ETB receptor increases BP to a lesser extent than CD ET-1 KO. These...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2604820/ https://ncbi.nlm.nih.gov/pubmed/18784261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90279.2008 |
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