Thrombin-mediated increases in cytosolic [Ca(2+)] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells

Thrombin is a procoagulant inflammatory agonist that can disrupt the endothelium-lumen barrier in the lung by causing contraction of endothelial cells and promote pulmonary cell proliferation. Both contraction and proliferation require increases in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)). In...

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Bibliographic Details
Main Authors: Sacks, Richard S., Firth, Amy L., Remillard, Carmelle V., Agange, Negin, Yau, Jocelyn, Ko, Eun A., Yuan, Jason X.-J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604792/
https://ncbi.nlm.nih.gov/pubmed/18836030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90259.2008
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