Cytokine-mediated inhibition of fibrillar amyloid-β peptide degradation by human mononuclear phagocytes

Vaccination therapy of AD animal models and patients strongly suggests an active role of brain mononuclear phagocytes in immune-mediated clearance of amyloid-β peptides (Aβ) in brain. Although Aβ uptake by macrophages can be regulated by pro- and anti-inflammatory cytokines, their effects on macroph...

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Bibliographic Details
Main Authors: Yamamoto, Masaru, Kiyota, Tomomi, Walsh, Shannon M., Liu, Jianuo, Kipnis, Jonathan, Ikezu, Tsuneya
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603577/
https://ncbi.nlm.nih.gov/pubmed/18768842
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