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Phenolic Bis-Styrylbenzenes as β-Amyloid Binding Ligands and Free Radical Scavengers

Starting from bisphenolic bis-styrylbenzene DF-9 (4), β-amyloid (Aβ) binding affinity and specificity for phenolic bis-styrylbenzenes, mono-styrylbenzenes and alkyne controls were determined by fluorescence titration with β-amyloid peptide Aβ(1-40) and a fluorescence assay using APP/PS1 transgenic m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Flaherty, Daniel P., Kiyota, Tomomi, Dong, Yuxiang, Ikezu, Tsuneya, Vennerstrom, Jonathan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057505/
https://ncbi.nlm.nih.gov/pubmed/21038854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1006929
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