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Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity

Inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinases,such as erlotinib and gefitinib, have not been very effective in the treatment of breast cancer although many breast cancer cells express EGFR. To address this apparent paradox, we examined possible predictors of the sensitivity...

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Autors principals: Yamasaki, Fumiyuki, Zhang, Dongwei, Bartholomeusz, Chandra, Sudo, Tamotsu, Hortobagyi, Gabriel N., Kurisu, Kaoru, Ueno, Naoto T.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603172/
https://ncbi.nlm.nih.gov/pubmed/17671085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-06-0514
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