Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance

Vinblastine and other microtubule inhibitors used as antimitotic cancer drugs characteristically promote the phosphorylation of the key anti-apoptotic protein, Bcl-xL. However, putative sites of phosphorylation have been inferred based on potential recognition by JNK, and no direct biochemical analy...

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Detalhes bibliográficos
Main Authors: Upreti, Meenakshi, Galitovskaya, Elena N., Chu, Rong, Tackett, Alan J., Terrano, David T., Granell, Susana, Chambers, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602892/
https://ncbi.nlm.nih.gov/pubmed/18974096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805019200
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