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S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2
S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signaling pathway that is involved in negative feedback regulation of insulin action. S6K1 is also activated by TNF-α, a pro-inflammatory cytokine. However, its role remains to be characterized. In the current study, we elucidated a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2602883/ https://ncbi.nlm.nih.gov/pubmed/18952604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806480200 |
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