α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells

Multiple system atrophy is a neurodegenerative disorder characterized by accumulation of aggregated Ser-129-phosphorylated α-synuclein in oligodendrocytes. p25α is an oligodendroglial protein that potently stimulates α-synuclein aggregation in vitro. To model multiple system atrophy, we coexpressed...

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Detalhes bibliográficos
Main Authors: Kragh, Christine L., Lund, Louise B., Febbraro, Fabia, Hansen, Hanne D., Gai, Wei-Ping, El-Agnaf, Omar, Richter-Landsberg, Christiane, Jensen, Poul Henning
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665075/
https://ncbi.nlm.nih.gov/pubmed/19203998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809671200
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