Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy

α-Synuclein (α-syn) positive glial cytoplasmic inclusions (GCI) originating in oligodendrocytes (ODC) are a characteristic hallmark in multiple system atrophy (MSA). Their occurrence may be linked to a failure of the ubiquitin proteasome system (UPS) or the autophagic pathway. For proteasomal degrad...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Pukaß, Katharina, Richter-Landsberg, Christiane
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419839/
https://ncbi.nlm.nih.gov/pubmed/25999815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00163
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