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ASSESSING SURROGATE ENDPOINTS IN VACCINE TRIALS WITH CASE-COHORT SAMPLING AND THE COX MODEL

Assessing immune responses to study vaccines as surrogates of protection plays a central role in vaccine clinical trials. Motivated by three ongoing or pending HIV vaccine efficacy trials, we consider such surrogate endpoint assessment in a randomized placebo-controlled trial with case-cohort sampli...

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Hlavní autoři: Qin, Li, Gilbert, Peter B., Follmann, Dean, Li, Dongfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2601643/
https://ncbi.nlm.nih.gov/pubmed/19079758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/07-AOAS132
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