The Role of MAP Kinase Phosphatase-1 in the Protective Mechanism of Dexamethasone against Endotoxemia

AIMS: We have previously shown that glucocorticoids induce the expression of MAP kinase phosphatase (Mkp)(a)-1 in innate immune cells. Since Mkp-1 is a critical negative regulator of the innate immune response, we hypothesize that Mkp-1 plays a significant role in the anti-inflammatory action of glu...

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Bibliografiske detaljer
Main Authors: Wang, Xianxi, Nelin, Leif D., Kuhlman, Joshua R., Meng, Xiaomei, Welty, Stephen E., Liu, Yusen
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600599/
https://ncbi.nlm.nih.gov/pubmed/18845168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2008.09.003
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