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Mitogen-activated Protein Kinase Phosphatase (Mkp)-1 Protects Mice against Acetaminophen-induced Hepatic Injury

c-Jun N-terminal kinase (JNK) activation promotes hepatocyte death during acetaminophen overdose, a common cause of drug-induced liver failure. While mitogen-activated protein kinase (MAPK) phosphatase (Mkp)-1 is a critical negative regulator of JNK MAPK, little is known about the role of Mkp-1 duri...

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Bibliografische gegevens
Hoofdauteurs: Wancket, Lyn M., Meng, Xiaomei, Rogers, Lynette K., Liu, Yusen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504636/
https://ncbi.nlm.nih.gov/pubmed/22623522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623312447551
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