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Widespread Impact of Nonsense-Mediated mRNA Decay on the Yeast Intronome
Nonsense mediated mRNA decay (NMD) eliminates transcripts carrying premature translation termination codons, but the role of NMD on yeast unspliced pre-mRNA degradation is controversial. Using tiling arrays we show that many unspliced yeast pre-mRNAs accumulate in strains mutated for the NMD compone...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2600495/ https://ncbi.nlm.nih.gov/pubmed/18691968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.005 |
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