Widespread Impact of Nonsense-Mediated mRNA Decay on the Yeast Intronome

Nonsense mediated mRNA decay (NMD) eliminates transcripts carrying premature translation termination codons, but the role of NMD on yeast unspliced pre-mRNA degradation is controversial. Using tiling arrays we show that many unspliced yeast pre-mRNAs accumulate in strains mutated for the NMD compone...

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Hlavní autoři: Sayani, Shakir, Janis, Michael, Lee, Chrissie Young, Toesca, Isabelle, Chanfreau, Guillaume F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600495/
https://ncbi.nlm.nih.gov/pubmed/18691968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.005
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